US Route 22 runs across Ohio, Pennsylvania, and New Jersey, ultimately connecting Cincinnati to Newark. US Route 22 has a great many branch routes, for being a US highway as short as it is; US Route 222, US Route 322, US Route 422, and US Route 522 all exist (a US Route 122 and a US Route 622 originally existed as well). The western end in downtown Cincinnati occurs at US Route 27, US Route 127, and US Route 42. In Ohio, US Route 22 runs east-northeast out of Cincinnati, serving as somewhat of a diagonal route. It passes through Wilmington, Circleville, Lancaster, and Zanesville, before crossing into West Virginia at Steubenville. US Route 22 only passes through the northern tip of West Virginia, crossing into Pennsylvania after a lousy five miles. In Pennsylvania, US Route 22 is a very important route, spanning the width of the state, across its middle. US Route 22 serves Pittsburgh, Harrisburg, and Easton, among other locales in Pennsylvania. US Route 22 hugs the route of Interstate 78 between eastern Pennsylvania and northern New Jersey. The eastern end of US Route 22 is at a complex interchange involving US Route 1 and US Route 9, just outside of Newark International Airport.
My photo of US Route 22 comes from a sign assembly positioned just south of Freeport, Ohio. Westbound travelers on US Route 22 will see this sign assembly as Ohio State Route 800 comes from the north and joins together with US Route 22. A concurrency of US Route 22 and Ohio State Route 800 continues ahead, bending southerly toward a split dividing those two routes. This photo was taken in March 2021 along a trip when I was collecting photos of Ohio State Highways.